Anti-TBX18 Antibody (PACO17217)

Antibody Name:	TBX18 Antibody (PACO17217)
Antibody SKU:	PACO17217
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human TBX18

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO17217(TBX18 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17217(TBX18 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors.

Synonyms:

T-box 18

UniProt Protein Function:	TBX18: Probable transcriptional regulator involved in developmental processes.
UniProt Protein Details:	Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 6q14-q15 Cellular Component: nucleus Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity; transcription factor activity Biological Process: anterior/posterior axis specification; morphogenesis of embryonic epithelium; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell-cell adhesion; positive regulation of epithelial cell proliferation; sensory perception of sound; smooth muscle cell differentiation; somitogenesis; transcription, DNA-dependent Disease: Huntington Disease
NCBI Summary:	This genes codes for a member of an evolutionarily conserved family of transcription factors that plays a crucial role in embryonic development. The family is characterized by the presence of the DNA-binding T-box domain and is divided into five sub-families based on sequence conservation in this domain. The encoded protein belongs to the vertebrate specific Tbx1 sub-family. The protein acts as a transcriptional repressor by antagonizing transcriptional activators in the T-box family. The protein forms homo- or heterodimers with other transcription factors of the T-box family or other transcription factors. [provided by RefSeq, Nov 2012]
UniProt Code:	O95935
NCBI GenInfo Identifier:	122937456
NCBI Gene ID:	9096
NCBI Accession:	NP_001073977.1
UniProt Secondary Accession:	O95935,Q7Z6U4, Q9UJI6, A2RU13,
UniProt Related Accession:	O95935
Molecular Weight:	80.8 kDa
NCBI Full Name:	T-box transcription factor TBX18
NCBI Synonym Full Names:	T-box 18
NCBI Official Symbol:	TBX18
NCBI Protein Information:	T-box transcription factor TBX18
UniProt Protein Name:	T-box transcription factor TBX18
Protein Family:	T-box transcription factor
UniProt Gene Name:	TBX18
UniProt Entry Name:	TBX18_HUMAN

Antibodies	ELISA Kits
TBX18 Antibody (PACO05688)	TBX18 Transcription Factor Activity Assay

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)