null

Anti-TGFBI Antibody (CAB2561)

SKU:
CAB2561
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 8 Anti-TGFBI Antibody CAB2561
  • Cell Biology Antibodies 8 Anti-TGFBI Antibody CAB2561
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TGFBI Antibody
Antibody SKU:CAB2561
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 481-683 of human TGFBI (NP_000349.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, Mouse heart, Mouse kidney, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 481-683 of human TGFBI (NP_000349.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AHDK RGRY GTLF TMDR VLTP PMGT VMDV LKGD NRFS MLVA AIQS AGLT ETLN REGV YTVF APTN EAFR ALPP RERS RLLG DAKE LANI LKYH IGDE ILVS GGIG ALVR LKSL QGDK LEVS LKNN VVSV NKEP VAEP DIMA TNGV VHVI TNVL QPPA NRPQ ERGD ELAD SALE IFKQ ASAF SRAS QRSV RLAP VYQK LLER MKH
Gene ID:7045
Uniprot:Q15582
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:74kDa
Observed MW:75kDa
Synonyms:TGFBI, BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1
Background:This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy.
UniProt Protein Function:betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Cell adhesion; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region; plasma membrane; basement membrane; trans-Golgi network

Molecular Function:collagen binding; integrin binding; protein binding; extracellular matrix binding

Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; negative regulation of cell adhesion; angiogenesis; cell adhesion

Disease: Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Lattice Type Iiia; Corneal Dystrophy, Avellino Type; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy, Groenouw Type I

NCBI Summary:This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Code:Q15582
NCBI GenInfo Identifier:2498193
NCBI Gene ID:7045
NCBI Accession:Q15582.1
UniProt Secondary Accession:Q15582,O14471, O14472, O14476, O43216, O43217, O43218 O43219, Q53XM1, D3DQB1,
UniProt Related Accession:Q15582
Molecular Weight:74,681 Da
NCBI Full Name:Transforming growth factor-beta-induced protein ig-h3
NCBI Synonym Full Names:transforming growth factor, beta-induced, 68kDa
NCBI Official Symbol:TGFBI  
NCBI Official Synonym Symbols:CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; BIGH3; CDGG1  
NCBI Protein Information:transforming growth factor-beta-induced protein ig-h3; RGD-CAP; beta ig-h3; kerato-epithelin; RGD-containing collagen-associated protein; transforming growth factor, beta-induced, 68kD
UniProt Protein Name:Transforming growth factor-beta-induced protein ig-h3
UniProt Synonym Protein Names:Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP
Protein Family:Transforming growth factor-beta-induced protein
UniProt Gene Name:TGFBI  
UniProt Entry Name:BGH3_HUMAN
Anti-TGFBI Antibody (CAB2561)Western blot analysis of extracts of various cell lines, using TGFBI antibody (CAB2561) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-TGFBI Antibody (CAB2561)Immunohistochemistry of paraffin-embedded human liver cancer using TGFBI Rabbit pAb (CAB2561) at dilution of 1:100 (40x lens).

Related Products