Thromboxane synthase Rabbit Monoclonal Antibody (CAB5173)

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CAB5173
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Technical Manual

Thromboxane synthase Rabbit Monoclonal Antibody

Product Name:Thromboxane synthase Rabbit Monoclonal Antibody
Product SKU:CAB5173
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Immunogen:A synthesized peptide derived from human Thromboxane synthase
Sequence:

Email for sequence

Gene ID:6916
Swiss Prot:P24557
Synonyms:BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
Calculated MW:54kDa
Observed MW:60KDa
Reactivity:Human, Mouse
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:A-549, Mouse lung, Mouse spleen
Cellular Location:

Product Images

Thromboxane synthase Rabbit Monoclonal Antibody (CAB5173)

Western blot - Thromboxane synthase Rabbit mAb (CAB5173)

Uniprot Information

UniProt Protein Function:TBXAS1: Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD). GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all. Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency). It is characterized by hemorrhagic diathesis. Belongs to the cytochrome P450 family.
UniProt Protein Details:

Protein type:Oxidoreductase; Lipid Metabolism - arachidonic acid; Membrane protein, integral; Membrane protein, multi-pass; Isomerase; EC 5.3.99.5

Chromosomal Location of Human Ortholog: 7q34-q35

Cellular Component: endoplasmic reticulum membrane

Molecular Function:thromboxane-A synthase activity

Biological Process: cyclooxygenase pathway; icosanoid metabolic process

Disease: Bleeding Disorder, Platelet-type, 14; Ghosal Hematodiaphyseal Dysplasia

NCBI Summary:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Code:P24557
NCBI GenInfo Identifier:254763392
NCBI Gene ID:6916
NCBI Accession:P24557.3
UniProt Secondary Accession:P24557,O14987, Q16843, Q16844, Q8IUN1, Q96CN2, Q9GZW4 Q9HD77, B4DJG6, E7EMU9, E7EP08, E7ESB5,
UniProt Related Accession:P24557
Molecular Weight:52,287 Da
NCBI Full Name:Thromboxane-A synthase
NCBI Synonym Full Names:thromboxane A synthase 1
NCBI Official Symbol:TBXAS1 
NCBI Official Synonym Symbols:TS; TXS; CYP5; THAS; TXAS; CYP5A1; GHOSAL; BDPLT14 
NCBI Protein Information:thromboxane-A synthase
UniProt Protein Name:Thromboxane-A synthase
UniProt Synonym Protein Names:Cytochrome P450 5A1
Protein Family:Thromboxane-A synthase
UniProt Gene Name:TBXAS1 
UniProt Entry Name:THAS_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
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