Anti-Thymidine glycol Antibody [B29]

Thymidine glycol Antibody [B29]

Thymidine glycol Antibody [B29] is a rabbit monoclonal antibody directed against Thymidine glycol, offered by Assay Genie for research applications. Reported applications include IHC and ELISA. Reported reactivity: Human. Supplied as IgG, purified by Affinity.

Thymidine glycol (TG) is a prominent oxidative DNA lesion formed when deoxythymidine undergoes oxidation, either directly or via reactive intermediates such as thymidine chlorohydrin. As a stable and abundant product of oxidative stress, TG serves as a critical biomarker of DNA damage in both nuclear and mitochondrial genomes. In the context of neuroscience, TG accumulation is increasingly recognized as a contributor to genomic instability in post-mitotic neurons, which are particularly vulnerable to oxidative damage due to high metabolic activity and limited DNA repair capacity. Elevated levels of TG have been detected in aging brain tissue and in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS), where oxidative stress and impaired DNA repair are central pathological features. TG lesions can interfere with DNA replication and transcription, leading to mutations, transcriptional arrest, and activation of DNA damage response pathways. If unrepaired, these lesions may trigger neuronal dysfunction, apoptosis, or chronic inflammation—key drivers of neurodegeneration. Understanding the formation, repair, and biological consequences of thymidine glycol is essential for elucidating the molecular mechanisms underlying neuronal aging and degeneration. As a sensitive indicator of oxidative DNA damage, TG also holds promise as a diagnostic and prognostic biomarker in neurodegenerative disease research. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.