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Anti-TIRAP Antibody (CAB1943)

SKU:
CAB1943
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-TIRAP Antibody CAB1943
  • Immunology Antibodies 2 Anti-TIRAP Antibody CAB1943
€139 - €419
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Description

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Antibody Name:Anti-TIRAP Antibody
Antibody SKU:CAB1943
Antibody Size:20uL, 50uL, 100uL
Application:IHC
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP (NP_001034750.1).
Application:IHC
Recommended Dilution:IHC 1:50 - 1:200
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human TIRAP (NP_001034750.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASS TSLP APGS RPKK PLGK MADW FRQT LLKK PKKR PNSP ESTS SDAS QPTS QDSP LPPS LSSV TSPS LPPT HASD SGSS RWSK DYDV CVCH SEED LVAA QDLV SYLE GSTA SLRC FLQL RDAT PGGA IVSE LCQA LSSS HCRV LLIT PGFL QDPW CKYQ MLQA LTEA PGAE GCTI PLLS GLSR AAYP PELR FMYY VDGR GPDG GFRQ VKEA VMRY LQTL S
Gene ID:114609
Uniprot:P58753
Cellular Location:Cell membrane, Cytoplasm, Membrane
Calculated MW:23kDa/25kDa/27kDa
Observed MW:
Synonyms:TIRAP, BACTS1, Mal, MyD88-2, wyatt
Background:The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
UniProt Protein Function:TIRAP: an adapter protein involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, ERK1, ERK2 and JNK, resulting in cytokine secretion and the inflammatory response. Homodimerizes. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9. Genetic variations in TIRAP can influence susceptibility or resistance to infectious diseases, including invasive pneumococcal disease, malaria and tuberculosis. Three isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q24.2

Cellular Component: nucleoplasm; intercellular bridge; endocytic vesicle; cytoplasm; plasma membrane; cytosol

Molecular Function:protein binding, bridging; protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein homodimerization activity; protein kinase C binding; protein heterodimerization activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; response to lipopolysaccharide; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; cell surface receptor linked signal transduction; positive regulation of interleukin-15 production; positive regulation of B cell proliferation; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor 2 signaling pathway; regulation of innate immune response; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to Gram-positive bacterium; toll-like receptor signaling pathway; innate immune response; myeloid cell differentiation; regulation of interferon-beta production

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Bacteremia, Susceptibility To, 1; Mycobacterium Tuberculosis, Susceptibility To; Malaria, Susceptibility To

NCBI Summary:The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
UniProt Code:P58753
NCBI GenInfo Identifier:50403750
NCBI Gene ID:114609
NCBI Accession:P58753.2
UniProt Secondary Accession:P58753,Q56UH9, Q56UI0, Q8N5E5, B3KW65,
UniProt Related Accession:P58753
Molecular Weight:221
NCBI Full Name:Toll/interleukin-1 receptor domain-containing adapter protein
NCBI Synonym Full Names:toll-interleukin 1 receptor (TIR) domain containing adaptor protein
NCBI Official Symbol:TIRAP  
NCBI Official Synonym Symbols:Mal; wyatt; BACTS1; MyD88-2  
NCBI Protein Information:toll/interleukin-1 receptor domain-containing adapter protein; adapter protein wyatt; adaptor protein Wyatt; MyD88 adapter-like protein; Toll-like receptor adaptor protein
UniProt Protein Name:Toll/interleukin-1 receptor domain-containing adapter protein
UniProt Synonym Protein Names:Adaptor protein Wyatt; MyD88 adapter-like protein; MyD88-2
Protein Family:Toll/interleukin-1 receptor domain-containing adapter protein
UniProt Gene Name:TIRAP  
UniProt Entry Name:TIRAP_HUMAN
Anti-TIRAP Antibody (CAB1943)Immunohistochemistry of paraffin-embedded human liver cancer using TIRAP antibody (CAB1943) at dilution of 1:200 (40x lens).
Anti-TIRAP Antibody (CAB1943)Immunohistochemistry of paraffin-embedded human colon carcinoma using TIRAP antibody (CAB1943) at dilution of 1:200 (40x lens).

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