The DR5/TRAILR2/TNFRSF10B Antibody (CAB1236) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. TNFRSF10B, also known as Death receptor 5 (DR5) or TRAIL receptor 2, is a member of the tumor necrosis factor receptor superfamily. It has been implicated in the induction of apoptosis in tumor cells, making it a potential therapeutic target for cancer research. By binding to TNFRSF10B, this antibody allows for the detection and analysis of this important protein in different cell types.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
DR5/TRAILR2/TNFRSF10B Antibody
SKU:
CAB1236
Size:
20μL, 100μL
Reactivity:
Human
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
Purification Method
Affinity purification
Gene ID
8795
RRID
AB_2759202
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using DR5/TRAILR2/TNFRSF10B Rabbit pAb (CAB1236) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
