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TNFRSF13C Rabbit Polyclonal Antibody (CAB14299)

SKU:
CAB14299
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:TNFRSF13C Rabbit Polyclonal Antibody
SKU:CAB14299
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human TNFRSF13C (NP_443177.1).
Sequence:MRRG PRSL RGRD APAP TPCV PAEC FDLL VRHC VACG LLRT PRPK PAGA SSPA PRTA LQPQ ESVG AGAG EAAL PLPG LLFG
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin; TNFRSF13C
Positive Sample:Raji,Daudi,SU-DHL-1
Conjugate:Unconjugated
Cellular Localization:Membrane, Single-pass type III membrane protein.
Calculated MW:19kDa
Observed MW:38kDa

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.

Purification Method:Affinity purification
Gene ID:115650
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using TNFRSF13C Rabbit pAb (CAB14299) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.

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