TNFSF10 Rabbit Polyclonal Antibody (CAB2138)
- SKU:
- CAB2138
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | TNFSF10 Rabbit Polyclonal Antibody |
SKU: | CAB2138 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human TNFSF10 (NP_003801.1). |
Sequence: | MAMM EVQG GPSL GQTC VLIV IFTV LLQS LCVA VTYV YFTN ELKQ MQDK YSKS GIAC FLKE DDSY WDPN DEES MNSP CWQV KWQL RQLV RKMI LRTS EETI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A; TNFSF10 |
Positive Sample: | THP-1 treated by LPS |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type II membrane protein. |
Calculated MW: | 33kDa |
Observed MW: | 28kDa |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 8743 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |