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Anti-TNFSF13B Antibody (CAB5858)

SKU:
CAB5858
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-TNFSF13B Antibody CAB5858
  • Immunology Antibodies 2 Anti-TNFSF13B Antibody CAB5858
€139 - €419
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Description

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Antibody Name:Anti-TNFSF13B Antibody
Antibody SKU:CAB5858
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 76-285 of human TNFSF13B (NP_006564.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HL-60, THP-1, A-549, HepG2, U-87MG, HeLa, A673, Mouse lung, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 76-285 of human TNFSF13B (NP_006564.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LASL RAEL QGHH AEKL PAGA GAPK AGLE EAPA VTAG LKIF EPPA PGEG NSSQ NSRN KRAV QGPE ETVT QDCL QLIA DSET PTIQ KGSY TFVP WLLS FKRG SALE EKEN KILV KETG YFFI YGQV LYTD KTYA MGHL IQRK KVHV FGDE LSLV TLFR CIQN MPET LPNN SCYS AGIA KLEE GDEL QLAI PREN AQIS LDGD VTFF GALK LL
Gene ID:10673
Uniprot:Q9Y275
Cellular Location:Cell membrane, Secreted, Single-pass type II membrane protein
Calculated MW:17kDa/29kDa/31kDa
Observed MW:42kDa
Synonyms:TNFSF13B, BAFF, BLYS, CD257, DTL, TALL-1, TALL1, THANK, TNFSF20, TNLG7A, ZTNF4
Background:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
UniProt Protein Function:BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Membrane protein, integral; Cytokine; Cell cycle regulation

Chromosomal Location of Human Ortholog: 13q32-q34

Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane

Molecular Function:protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; T cell costimulation; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; signal transduction

NCBI Summary:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
UniProt Code:Q9Y275
NCBI GenInfo Identifier:13124573
NCBI Gene ID:10673
NCBI Accession:Q9Y275.1
UniProt Secondary Accession:Q9Y275,Q6FHD6, Q7Z5J2, E0ADT7,
UniProt Related Accession:Q9Y275
Molecular Weight:17,578 Da
NCBI Full Name:Tumor necrosis factor ligand superfamily member 13B
NCBI Synonym Full Names:tumor necrosis factor (ligand) superfamily, member 13b
NCBI Official Symbol:TNFSF13B  
NCBI Official Synonym Symbols:DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20  
NCBI Protein Information:tumor necrosis factor ligand superfamily member 13B; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 13B
UniProt Synonym Protein Names:B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD_antigen: CD257Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form
UniProt Gene Name:TNFSF13B  
UniProt Entry Name:TN13B_HUMAN
Anti-TNFSF13B Antibody (CAB5858)Western blot analysis of extracts of various cell lines, using TNFSF13B antibody (CAB5858) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s.
Anti-TNFSF13B Antibody (CAB5858)Immunohistochemistry of paraffin-embedded mouse kidney using TNFSF13B Rabbit pAb (CAB5858) at dilution of 1:100 (40x lens).

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