null

Anti-TNNI2 Antibody (CAB4740)

SKU:
CAB4740
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-TNNI2 Antibody
Antibody SKU:CAB4740
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TNNI2
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse lung, Mouse skeletal muscle, Rat skeletal muscle
Immunogen:A synthesized peptide derived from human TNNI2
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7136
Uniprot:P48788
Cellular Location:
Calculated MW:21kDa
Observed MW:21KDa
Synonyms:AMCD2B, DA2B, FSSV, fsTnI
Background:This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Protein Function:TNNI2: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B); also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin. Belongs to the troponin I family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: troponin complex; cytosol; nucleus

Molecular Function:troponin T binding; protein binding; actin binding

Biological Process: skeletal muscle contraction; regulation of muscle contraction; positive regulation of transcription, DNA-dependent; muscle filament sliding

Disease: Arthrogryposis, Distal, Type 2b

NCBI Summary:This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Code:P48788
NCBI GenInfo Identifier:1351297
NCBI Gene ID:7136
NCBI Accession:P48788.2
UniProt Secondary Accession:P48788,A6NIV8, A6NJU5,
UniProt Related Accession:P48788
Molecular Weight:182
NCBI Full Name:Troponin I, fast skeletal muscle
NCBI Synonym Full Names:troponin I type 2 (skeletal, fast)
NCBI Official Symbol:TNNI2  
NCBI Official Synonym Symbols:DA2B; FSSV; fsTnI; AMCD2B  
NCBI Protein Information:troponin I, fast skeletal muscle; troponin I fast twitch 2; troponin I, skeletal, fast; troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform
UniProt Protein Name:Troponin I, fast skeletal muscle
UniProt Synonym Protein Names:Troponin I, fast-twitch isoform
Protein Family:Troponin
UniProt Gene Name:TNNI2  
UniProt Entry Name:TNNI2_HUMAN
Anti-TNNI2 Antibody (CAB4740)Western blot - TNNI2 Rabbit mAb (CAB4740)

Related Products