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Anti-TRIP10 Antibody (CAB7038)

SKU:
CAB7038
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 10 Anti-TRIP10 Antibody CAB7038
  • Cell Biology Antibodies 10 Anti-TRIP10 Antibody CAB7038
$167 - $503
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Description

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Antibody Name:Anti-TRIP10 Antibody
Antibody SKU:CAB7038
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 246-545 of human TRIP10 (NP_004231.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:HepG2, HeLa, SKOV3, A673, 5637, Mouse kidney, Mouse heart, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 246-545 of human TRIP10 (NP_004231.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AKCL EGMK VAAN AVDP KNDS HVLI ELHK SGFA RPGD VEFE DFSQ PMNR APSD SSLG TPSD GRPE LRGP GRSR TKRW PFGK KNKT VVTE DFSH LPPE QQRK RLQQ QLEE RSRE LQKE VDQR EALK KMKD VYEK TPQM GDPA SLEP QIAE TLSN IERL KLEV QKYE AWLA EAES RVLS NRGD SLSR HARP PDPP ASAP PDSS SNSA SQDT KESS EEPP SEES QDTP IYTE FDED FEEE PTSP IGHC VAIY HFEG SSEG TISM AEGE DLSL MEED KGDG WTRV RRKE GGEG YVPT SYLR VTLN
Gene ID:9322
Uniprot:Q15642
Cellular Location:Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Lysosome, cell cortex, cytoskeleton, perinuclear region, phagocytic cup
Calculated MW:39kDa/52kDa/62kDa/67kDa/68kDa
Observed MW:90kDa
Synonyms:TRIP10, CIP4, HSTP, STOT, STP, TRIP-10
Background:
UniProt Protein Function:TRIP10: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N- WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL. Belongs to the FNBP1 family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; Golgi apparatus; cell projection; cytoskeleton; intracellular membrane-bound organelle; lysosome; perinuclear region of cytoplasm; cytoplasm; cell cortex; cytosol; phagocytic cup

Molecular Function:identical protein binding; protein binding; lipid binding

Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; endocytosis; cell communication; actin cytoskeleton organization and biogenesis; signal transduction

UniProt Code:Q15642
NCBI GenInfo Identifier:118572632
NCBI Gene ID:9322
NCBI Accession:Q15642.3
UniProt Related Accession:Q15642
Molecular Weight:39kDa; 52kDa; 62kDa; 67kDa; 68kDa
NCBI Full Name:Cdc42-interacting protein 4
NCBI Synonym Full Names:thyroid hormone receptor interactor 10
NCBI Official Symbol:TRIP10  
NCBI Official Synonym Symbols:STP; CIP4; HSTP; STOT; TRIP-10  
NCBI Protein Information:cdc42-interacting protein 4
UniProt Protein Name:Cdc42-interacting protein 4
UniProt Synonym Protein Names:Protein Felic; Salt tolerant protein; hSTP; Thyroid receptor-interacting protein 10; TR-interacting protein 10; TRIP-10
Protein Family:Cdc42-interacting protein
UniProt Gene Name:TRIP10  
UniProt Entry Name:CIP4_HUMAN
Anti-TRIP10 Antibody (CAB7038)Western blot analysis of extracts of various cell lines, using TRIP10 antibody (CAB7038) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-TRIP10 Antibody (CAB7038)Immunofluorescence analysis of U2OS cells using TRIP10 antibody (CAB7038). Blue: DAPI for nuclear staining.

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