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Anti-UBE2S Antibody (CAB4658)

SKU:
CAB4658
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
UBE2S
E2-EPF
E2EPF
EPF5
Research Area:
Cell Cycle
  • Cell Cycle Antibodies 1 Anti-UBE2S Antibody CAB4658
  • Cell Cycle Antibodies 1 Anti-UBE2S Antibody CAB4658
  • Cell Cycle Antibodies 1 Anti-UBE2S Antibody CAB4658
  • Cell Cycle Antibodies 1 Anti-UBE2S Antibody CAB4658
  • Cell Cycle Antibodies 1 Anti-UBE2S Antibody CAB4658
  • Cell Cycle Antibodies 1 Anti-UBE2S Antibody CAB4658
€139 - €419
Frequently bought together:

Description

Product Name:UBE2S Rabbit pAb
Product Code:CAB4658
Size:20uL, 50uL, 100uL
Synonyms:UBE2S, E2-EPF, E2EPF, EPF5
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 122-221 of human UBE2S (NP_055316.2).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, A-431, HeLa, 22Rv1, BT-474, Mouse spleen, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 122-221 of human UBE2S (NP_055316.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HPNP ESAL NEEA GRLL LENY EEYA ARAR LLTE IHGG AGGP SGRA EAGR ALAS GTEA SSTD PGAP GGPG GAEG PMAK KHAG ERDK KLAA KKKT DKKR ALRR
Gene ID:27338
Uniprot:Q16763
Calculated MW:23kDa
Observed MW:24kDa
UniProt Protein Function:UBE2S: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL. Belongs to the ubiquitin-conjugating enzyme family.
UniProt Protein Details:

Protein type:Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system; Ligase

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: anaphase-promoting complex; cytoplasm

Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: anaphase-promoting complex activation; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; protein modification process; exit from mitosis

NCBI Summary:This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
UniProt Code:Q16763
NCBI GenInfo Identifier:23829978
NCBI Gene ID:27338
NCBI Accession:Q16763.2
UniProt Related Accession:Q16763
Molecular Weight:
NCBI Full Name:Ubiquitin-conjugating enzyme E2 S
NCBI Synonym Full Names:ubiquitin conjugating enzyme E2 S
NCBI Official Symbol:UBE2S  
NCBI Official Synonym Symbols:EPF5; E2EPF; E2-EPF  
NCBI Protein Information:ubiquitin-conjugating enzyme E2 S
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 S
UniProt Synonym Protein Names:E2-EPF; Ubiquitin carrier protein S; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; Ubiquitin-protein ligase S
Protein Family:Ubiquitin-conjugating enzyme
UniProt Gene Name:UBE2S  
UniProt Entry Name:UBE2S_HUMAN

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