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Anti-VTI1B Antibody (CAB7062)

SKU:
CAB7062
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 10 Anti-VTI1B Antibody CAB7062
  • Cell Biology Antibodies 10 Anti-VTI1B Antibody CAB7062
  • Cell Biology Antibodies 10 Anti-VTI1B Antibody CAB7062
  • Cell Biology Antibodies 10 Anti-VTI1B Antibody CAB7062
€139 - €419
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Description

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Antibody Name:Anti-VTI1B Antibody
Antibody SKU:CAB7062
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human VTI1B (NP_006361.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human VTI1B (NP_006361.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASS AASS EHFE KLHE IFRG LHED LQGV PERL LGTA GTEE KKKL IRDF DEKQ QEAN ETLA EMEE ELRY APLS FRNP MMSK LRNY RKDL AKLH REVR STPL TATP GGRG DMKY GIYA VENE HMNR LQSQ RAML LQGT ESLN RATQ SIER SHRI ATET DQIG SEII EELG EQRD QLER TKSR LVNT SENL SKSR KILR SMSR KVTT NKLL LS
Gene ID:10490
Uniprot:Q9UEU0
Cellular Location:Cytoplasmic granule, Late endosome membrane, Lysosome membrane, Single-pass type IV membrane protein
Calculated MW:19kDa/26kDa
Observed MW:27kDa
Synonyms:VTI1B, VTI1, VTI1-LIKE, VTI1L, VTI2, v-SNARE, vti1-rp1
Background:
UniProt Protein Function:VTI1B: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; intracellular membrane-bound organelle; late endosome membrane; lysosomal membrane; integral to membrane; SNARE complex; synaptic vesicle; recycling endosome; cell soma; perinuclear region of cytoplasm; cytoplasm; vesicle

Molecular Function:SNAP receptor activity; SNARE binding; chloride channel inhibitor activity

Biological Process: vesicle-mediated transport; intra-Golgi vesicle-mediated transport; cell proliferation; ER to Golgi vesicle-mediated transport; autophagic vacuole fusion; Golgi to vacuole transport; vesicle fusion with Golgi apparatus; protein targeting to vacuole; retrograde transport, endosome to Golgi; vesicle docking during exocytosis

UniProt Code:Q9UEU0
NCBI GenInfo Identifier:126302613
NCBI Gene ID:10490
NCBI Accession:Q9UEU0.3
UniProt Secondary Accession:Q9UEU0,O43547, Q96J28,
UniProt Related Accession:Q9UEU0
Molecular Weight:232
NCBI Full Name:Vesicle transport through interaction with t-SNAREs homolog 1B
NCBI Synonym Full Names:vesicle transport through interaction with t-SNAREs 1B
NCBI Official Symbol:VTI1B  
NCBI Official Synonym Symbols:VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE  
NCBI Protein Information:vesicle transport through interaction with t-SNAREs homolog 1B; vesicle transport v-SNARE protein Vti1-like 1; vesicle-associated soluble NSF attachment protein receptor
UniProt Protein Name:Vesicle transport through interaction with t-SNAREs homolog 1B
UniProt Synonym Protein Names:Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1
Protein Family:Vesicle transport through interaction with t-SNAREs
UniProt Gene Name:VTI1B  
UniProt Entry Name:VTI1B_HUMAN
Anti-VTI1B Antibody (CAB7062)Western blot analysis of extracts of mouse brain, using VTI1B antibody (CAB7062) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-VTI1B Antibody (CAB7062)Immunohistochemistry of paraffin-embedded human liver cancer using VTI1B antibody (CAB7062) at dilution of 1:100 (40x lens).
Anti-VTI1B Antibody (CAB7062)Immunohistochemistry of paraffin-embedded human esophageal cancer using VTI1B antibody (CAB7062) at dilution of 1:100 (40x lens).
Anti-VTI1B Antibody (CAB7062)Immunofluorescence analysis of U2OS cells using VTI1B antibody (CAB7062). Blue: DAPI for nuclear staining.

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