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Anti-WDR11 Antibody (CAB10590)

SKU:
CAB10590
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-WDR11 Antibody
Antibody SKU:CAB10590
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 975-1224 of human WDR11 (NP_060587.8).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:DU145, HL-60, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 975-1224 of human WDR11 (NP_060587.8).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YFQK FQLE RVNL QEVK RSTY DHTR KCTD QLLL LGQT DRAV QLLL ETSA DNQH YYCD SLKA CLVT TVTS SGPS QSTI KLVA TNMI ANGK LAEG VQLL CLID KAAD ACRY LQTY GEWN RAAW LAKV RLNP EECA DVLR RWVD HLCS PQVN QKSK ALLV LLSL GCFF SVAE TLHS MRYF DRAA LFVE ACLK YGAF EVTE DTEK LITA IYAD YARS LKNL GFKQ GAVL FASK AGAA GKDL LNEL ESPK EEPI EE
Gene ID:55717
Uniprot:Q9BZH6
Cellular Location:Cytoplasm, Membrane, Nucleus, Single-pass membrane protein
Calculated MW:136kDa
Observed MW:130kDa
Synonyms:WDR11, BRWD2, DR11, HH14, SRI1, WDR15
Background:This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
UniProt Protein Function:BRWD2: a protein with two WD40 domains. A translocation of BRWD2 with ZNF320 is found in a form of glioblastoma (t(10;19)(q26;q13.3)).
UniProt Protein Details:

Protein type:Membrane protein, integral; Oncoprotein

Chromosomal Location of Human Ortholog: 10q26.12

Cellular Component: cytoplasm; cytosol; lysosomal membrane; membrane; microtubule cytoskeleton

Molecular Function:protein binding

Disease: Hypogonadotropic Hypogonadism 14 With Or Without Anosmia; Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

NCBI Summary:This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BZH6
NCBI GenInfo Identifier:17368715
NCBI Gene ID:55717
NCBI Accession:Q9BZH6.1
UniProt Secondary Accession:Q9BZH6,Q5VWA1, Q9P2J6,
UniProt Related Accession:Q9BZH6
Molecular Weight:137kDa
NCBI Full Name:WD repeat-containing protein 11
NCBI Synonym Full Names:WD repeat domain 11
NCBI Official Symbol:WDR11  
NCBI Official Synonym Symbols:DR11; HH14; SRI1; BRWD2; WDR15  
NCBI Protein Information:WD repeat-containing protein 11
UniProt Protein Name:WD repeat-containing protein 11
UniProt Synonym Protein Names:Bromodomain and WD repeat-containing protein 2; WD repeat-containing protein 15
Protein Family:WD repeat-containing protein
UniProt Gene Name:WDR11  
Anti-WDR11 Antibody (CAB10590)Western blot analysis of extracts of various cell lines, using WDR11 antibody (CAB10590) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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