Anti-Xanthine Oxidase Antibody (CAB9022)

SKU:
CAB9022
€129 - €349

Description

Technical Manual

Anti-Xanthine Oxidase Antibody

Product Name:Anti-Xanthine Oxidase Antibody
Product SKU:CAB9022
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]

Immunogen:A synthesized peptide derived from human Xanthine Oxidase
Sequence:

Email for sequence

Gene ID:7498
Swiss Prot:P47989
Synonyms:XAN1; XO; XOR
Calculated MW:146kDa
Observed MW:150KDa
Reactivity:Human, Mouse, Rat
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting Immunohistochemistry Immunofluorescence
Positive Samples:HepG2, Rat lung
Cellular Location:

Product Images

Anti-Xanthine Oxidase Antibody (CAB9022)

Western blot - Xanthine Oxidase Rabbit mAb (CAB9022)

Uniprot Information

UniProt Protein Function:XDH: Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro). Defects in XDH are the cause of xanthinuria type 1 (XU1). Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol. Belongs to the xanthine dehydrogenase family.
UniProt Protein Details:

Protein type:EC 1.17.1.4; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - purine; EC 1.17.3.2; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p23.1

Cellular Component: cytosol; extracellular space

Molecular Function:2 iron, 2 sulfur cluster binding; FAD binding; molybdopterin cofactor binding; oxidoreductase activity, acting on the aldehyde or oxo group of donors; protein homodimerization activity; xanthine dehydrogenase activity; xanthine oxidase activity

Biological Process: caspase activation; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell proliferation; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase B signaling cascade; purine nucleotide catabolic process; xanthine catabolic process

Disease: Xanthinuria, Type I

NCBI Summary:Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014]
UniProt Code:P47989
NCBI GenInfo Identifier:2506326
NCBI Gene ID:7498
NCBI Accession:P47989.4
UniProt Secondary Accession:P47989,Q16681, Q16712, Q4PJ16,
UniProt Related Accession:P47989
Molecular Weight:146,424 Da
NCBI Full Name:Xanthine dehydrogenase/oxidase
NCBI Synonym Full Names:xanthine dehydrogenase
NCBI Official Symbol:XDH
NCBI Official Synonym Symbols:XO; XOR
NCBI Protein Information:xanthine dehydrogenase/oxidase
UniProt Protein Name:Xanthine dehydrogenase/oxidase
UniProt Synonym Protein Names:Xanthine oxidoreductase; XOR
Protein Family:Xanthine dehydrogenase
UniProt Gene Name:XDH
UniProt Entry Name:XDH_HUMAN
View AllClose

Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
View AllClose