The YTHDC2 Antibody (CAB15004) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.YTHDC2 is a member of the YTH domain-containing family of proteins, which play important roles in RNA splicing and processing. The protein is known to interact with m6A-modified RNA, suggesting a role in the regulation of RNA stability and translation.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
YTHDC2 Antibody
SKU:
CAB15004
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
CAHL, hYTHDC2, YTHDC2
Positive Sample:
HeLa, Mouse testis, Rat testis
Cellular Localization:
Endoplasmic Reticulum, Nucleus, Perinuclear Region Of Cytoplasm.
Calculated MW:
160kDa
Observed MW:
160kDa
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line.
Purification Method
Affinity purification
Gene ID
64848
RRID
AB_2761887
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using YTHDC2 Rabbit pAb (CAB15004) at 1:3000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
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