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ABCC5 Rabbit Polyclonal Antibody (CAB3028)

SKU:
CAB3028
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€139 - €419
Frequently bought together:

Description

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Product Name:ABCC5 Rabbit Polyclonal Antibody
SKU:CAB3028
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ABCC5 (NP_005679.2).
Sequence:MKDI DIGK EYII PSPG YRSV RERT STSG THRD REDS KFRR TRPL ECQD ALET AARA EGLS LDAS MHSQ LRIL DEEH PKGK YHHG LSAL KPIR TTSK HQHP VDNA GLFS CMTF SWLS SLAR VAHK KGEL SMED VWSL SKHE SSDV NCRR LERL WQEE LNEV GPDA ASLR RVVW IFCR TRL
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:2000
Synonyms:MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145; ABCC5
Positive Sample:Mouse brain,Mouse lung,Rat brain
Conjugate:Unconjugated
Cellular Localization:Membrane, Multi-pass membrane protein.
Calculated MW:161kDa
Observed MW:185kDa

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:10057
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using ABCC5 antibody (CAB3028) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.

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