Anti-ABCD3 Antibody (CAB18177)

Antibody Name:	Anti-ABCD3 Antibody
Antibody SKU:	CAB18177
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant protein of human ABCD3.

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	HeLa, HepG2, Mouse liver, Mouse kidney, Rat liver

Immunogen:	Recombinant protein of human ABCD3.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	5825
Uniprot:	P28288
Cellular Location:
Calculated MW:
Observed MW:	70KDa

Western blot - ABCD3 Rabbit pAb (CAB18177)

Synonyms:

ABC43, CBAS5, PMP70, PXMP1, ZWS2, ABCD3

Background:

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

UniProt Protein Function:	ABCD3: a member of the superfamily of ATP-binding cassette (ABC) transporters. Likely plays an important role in peroxisome biogenesis. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. Defects in ABCD3 may be the cause of Zellweger syndrome-2 (ZWS-2), an autosomal recessive disorder due to defective import mechanisms for peroxisomal matrix enzymes.
UniProt Protein Details:	Protein type:Membrane protein, multi-pass; Transporter, ABC family; Transporter; Membrane protein, integral; Mitochondrial Chromosomal Location of Human Ortholog: 1p21.3 Cellular Component: peroxisomal membrane; peroxisomal matrix; membrane; intracellular membrane-bound organelle; mitochondrial inner membrane; integral to membrane; peroxisome; cytosol Molecular Function:protein binding; protein homodimerization activity; ATPase activity, coupled to transmembrane movement of substances; ATPase activity; ATP binding Biological Process: fatty acid beta-oxidation; very-long-chain fatty acid catabolic process; peroxisome organization and biogenesis; transmembrane transport Disease: Bile Acid Synthesis Defect, Congenital, 5
NCBI Summary:	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:	P28288
NCBI GenInfo Identifier:	130358
NCBI Gene ID:	5825
NCBI Accession:	P28288.1
UniProt Related Accession:	P28288
Molecular Weight:	70kDa
NCBI Full Name:	ATP-binding cassette sub-family D member 3
NCBI Synonym Full Names:	ATP binding cassette subfamily D member 3
NCBI Official Symbol:	ABCD3
NCBI Official Synonym Symbols:	ZWS2; ABC43; CBAS5; PMP70; PXMP1
NCBI Protein Information:	ATP-binding cassette sub-family D member 3
UniProt Protein Name:	ATP-binding cassette sub-family D member 3
UniProt Synonym Protein Names:	70 kDa peroxisomal membrane protein; PMP70
UniProt Gene Name:	ABCD3
UniProt Entry Name:	ABCD3_HUMAN

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)