The ADAMTS13 Monoclonal Antibody (CAB3370) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced through rabbit immunization, is highly specific to human ADAMTS13 and has been validated for use in various applications, including Western blotting.ADAMTS13 plays a crucial role in preventing excessive blood clotting by cleaving a large von Willebrand factor (VWF) protein. Dysregulation of ADAMTS13 function has been implicated in various thrombotic disorders, making it a promising target for therapeutic interventions.
This antibody is validated for use in WB, ELISA, IF-P applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
ADAMTS13 Monoclonal Antibody
SKU:
CAB3370
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC1957
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
11093
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using ADAMTS13 Rabbit mAb (CAB3370) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 180s.
Immunofluorescence analysis of paraffin-embedded rat liver using ADAMTS13 Rabbit mAb (CAB3370) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of paraffin-embedded mouse liver using ADAMTS13 Rabbit mAb (CAB3370) at dilution of 1:100 (40x lens). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
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