CLOCK Rabbit Monoclonal Antibody (CAB7265)
- SKU:
- CAB7265
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- KAT13D
- bHLHe8
Description
Product Name: | CLOCK Rabbit Monoclonal Antibody |
SKU: | CAB7265 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CLOCK (NP_004889.1). |
Sequence: | WKPT FLSN EEFT QLML EALD GFFL AIMT DGSI IYVS ESVT SLLE HLPS DLVD QSIF NFIP EGEH SEVY KILS THLL ESDS LTPE YLKS KNQL EFCC HMLR G |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | KAT13D; bHLHe8; CLOCK |
Positive Sample: | HeLa,293T,NIH/3T3,SH-SY5Y,Mouse lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 95kDa |
Observed MW: | 95kDa |
The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 9575 |
Clone Number: | ARC1819 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |