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Anti-CC2D1A Antibody (CAB19283)

SKU:
CAB19283
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CC2D1A
FREUD-1
Freud-1/Aki1
MRT3
coiled-coil and C2 domain containing 1A
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
Frequently bought together:

Description

Product Name:CC2D1A Rabbit mAb
Product Code:CAB19283
Size:20uL, 50uL, 100uL
Synonyms:CC2D1A, FREUD-1, Freud-1/Aki1, MRT3, coiled-coil and C2 domain containing 1A
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CC2D1A.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, U-251MG, Mouse testis, Mouse brain
Immunogen:Recombinant protein of human CC2D1A.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:54862
Uniprot:Q6P1N0
Cellular Location:Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:130kDa
Observed MW:130KDa
UniProt Protein Function:CC2D1A: a transcription factor that binds specifically to the FRE (five repressor element) and represses 5- HT1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of 5- HT1A associated with anxiety and major depression. Mediates HDAC-independent repression of 5- HT1A promoter in neuronal cells. Three alternatively spliced human isoforms have been described.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: membrane; cytoplasm; microtubule organizing center; nucleus

Molecular Function:signal transducer activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; signal transduction

Disease: Mental Retardation, Autosomal Recessive 3

NCBI Summary:This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]
UniProt Code:Q6P1N0
NCBI GenInfo Identifier:74737148
NCBI Gene ID:54862
NCBI Accession:Q6P1N0.1
UniProt Related Accession:Q6P1N0
Molecular Weight:
NCBI Full Name:Coiled-coil and C2 domain-containing protein 1A
NCBI Synonym Full Names:coiled-coil and C2 domain containing 1A
NCBI Official Symbol:CC2D1A  
NCBI Official Synonym Symbols:MRT3; FREUD-1; Freud-1/Aki1  
NCBI Protein Information:coiled-coil and C2 domain-containing protein 1A
UniProt Protein Name:Coiled-coil and C2 domain-containing protein 1A
UniProt Synonym Protein Names:Akt kinase-interacting protein 1; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1; Putative NF-kappa-B-activating protein 023N
UniProt Gene Name:CC2D1A  
UniProt Entry Name:C2D1A_HUMAN

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