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Anti-CC2D1A Antibody (CAB4800)

SKU:
CAB4800
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CC2D1A
FREUD-1
Freud-1/Aki1
MRT3
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-CC2D1A Antibody CAB4800
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-CC2D1A Antibody CAB4800
€139 - €419
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Description

Product Name:CC2D1A Rabbit pAb
Product Code:CAB4800
Size:20uL, 50uL, 100uL
Synonyms:CC2D1A, FREUD-1, Freud-1/Aki1, MRT3
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CC2D1A (NP_060191.3).
Applications:WB, IHC
Recommended Dilutions:WB 1:1000 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, SKOV3, 293T, A-549, LO2, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CC2D1A (NP_060191.3).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MHKR KGPP GPPG RGAA AARQ LGLL VDLS PDGL MIPE DGAN DEEL EAEF LALV GGQP PALE KLKG KGPL PMEA IEKM ASLC MRDP DEDE EEGT DEDD LEAD DDLL AELN EVLG EEQK ASET PPPV AQPK PEAP HPGL ETTL QERL ALYQ TA
Gene ID:54862
Uniprot:Q6P1N0
Cellular Location:Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:103kDa/104kDa
Observed MW:131kDa
UniProt Protein Function:CC2D1A: a transcription factor that binds specifically to the FRE (five repressor element) and represses 5- HT1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of 5- HT1A associated with anxiety and major depression. Mediates HDAC-independent repression of 5- HT1A promoter in neuronal cells. Three alternatively spliced human isoforms have been described.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: membrane; cytoplasm; microtubule organizing center; nucleus

Molecular Function:signal transducer activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; signal transduction

Disease: Mental Retardation, Autosomal Recessive 3

NCBI Summary:This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in a nonsyndromic form of cognitive disability (MRT3). [provided by RefSeq, Jul 2017]
UniProt Code:Q6P1N0
NCBI GenInfo Identifier:74737148
NCBI Gene ID:54862
NCBI Accession:Q6P1N0.1
UniProt Related Accession:Q6P1N0
Molecular Weight:
NCBI Full Name:Coiled-coil and C2 domain-containing protein 1A
NCBI Synonym Full Names:coiled-coil and C2 domain containing 1A
NCBI Official Symbol:CC2D1A  
NCBI Official Synonym Symbols:MRT3; FREUD-1; Freud-1/Aki1  
NCBI Protein Information:coiled-coil and C2 domain-containing protein 1A
UniProt Protein Name:Coiled-coil and C2 domain-containing protein 1A
UniProt Synonym Protein Names:Akt kinase-interacting protein 1; Five prime repressor element under dual repression-binding protein 1; FRE under dual repression-binding protein 1; Freud-1; Putative NF-kappa-B-activating protein 023N
UniProt Gene Name:CC2D1A  
UniProt Entry Name:C2D1A_HUMAN

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