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Anti-Ceruloplasmin Antibody (CAB20229)

SKU:
CAB20229
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CP
CP-2
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:Ceruloplasmin Rabbit mAb
Product Code:CAB20229
Size:20uL, 50uL, 100uL
Synonyms:CP, CP-2
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human Ceruloplasmin.
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse serum, Rat testis, Rat serum
Immunogen:A synthetic peptide of human Ceruloplasmin.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1356
Uniprot:P00450
Cellular Location:Secreted
Calculated MW:122kDa
Observed MW:140KDa
UniProt Protein Function:CP: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. Defects in CP are the cause of aceruloplasminemia (ACERULOP). It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Belongs to the multicopper oxidase family.
UniProt Protein Details:

Protein type:Secreted; EC 1.16.3.1; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q23-q25

Cellular Component: extracellular space; lysosomal membrane; extracellular region

Molecular Function:ferroxidase activity; copper ion binding; chaperone binding

Biological Process: cellular iron ion homeostasis; copper ion transport; transmembrane transport

Disease: Aceruloplasminemia

UniProt Code:P00450
NCBI GenInfo Identifier:4557485
NCBI Gene ID:1356
NCBI Accession:NP_000087
UniProt Related Accession:P00450
Molecular Weight:122,205 Da
NCBI Full Name:ceruloplasmin
NCBI Synonym Full Names:ceruloplasmin (ferroxidase)
NCBI Official Symbol:CP  
NCBI Official Synonym Symbols:CP-2  
NCBI Protein Information:ceruloplasmin
UniProt Protein Name:Ceruloplasmin
UniProt Synonym Protein Names:Ferroxidase
Protein Family:Ceruloplasmin
UniProt Gene Name:CP  
UniProt Entry Name:CERU_HUMAN

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