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CLDN6 Rabbit Polyclonal Antibody (CAB20465)

SKU:
CAB20465
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
€139 - €419
Frequently bought together:

Description

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Product Name:CLDN6 Rabbit Polyclonal Antibody
SKU:CAB20465
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 121-220 of human Claudin 6 (NP_067018.2).
Sequence:SGIV FVIS GVLT LIPV CWTA HAII RDFY NPLV AEAQ KREL GASL YLGW AASG LLLL GGGL LCCT CPSG GSQG PSHY MARY STSA PAIS RGPS EYPT KNYV
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Positive Sample:OVCAR3,Rat brain
Conjugate:Unconjugated
Cellular Localization:apicolateral plasma membrane, bicellular tight junction, plasma membrane
Calculated MW:23kDa
Observed MW:23kDa

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

Purification Method:Affinity purification
Gene ID:9074
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of OVCAR3 cells, using Claudin 6 antibody (CAB20465) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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