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Anti-CLDN6 Antibody (CAB20465)

SKU:
CAB20465
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
$167 - $503
Frequently bought together:

Description

Product Name:CLDN6 Rabbit pAb
Product Code:CAB20465
Size:50uL, 100uL
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human CLDN6.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:OVCAR3, Rat brain
Immunogen:Recombinant protein of human CLDN6.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9074
Uniprot:P56747
Calculated MW:23kDa
Observed MW:23KDa
UniProt Protein Function:Claudin-6: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: tight junction

Molecular Function:identical protein binding

Biological Process: calcium-independent cell-cell adhesion

NCBI Summary:Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
UniProt Code:P56747
NCBI GenInfo Identifier:90183180
NCBI Gene ID:9074
NCBI Accession:P56747.2
UniProt Secondary Accession:P56747,B3KQP9, D3DUA5,
UniProt Related Accession:P56747
Molecular Weight:23,292 Da
NCBI Full Name:Claudin-6
NCBI Synonym Full Names:claudin 6
NCBI Official Symbol:CLDN6  
NCBI Protein Information:claudin-6
UniProt Protein Name:Claudin-6
UniProt Synonym Protein Names:Skullin
Protein Family:Claudin
UniProt Gene Name:CLDN6  
UniProt Entry Name:CLD6_HUMAN

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