Anti-COPS3 Antibody (CAB19584)
- SKU:
- CAB19584
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CSN3
- SGN3
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Product Name: | COPS3 Rabbit mAb |
| Product Code: | CAB19584 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CSN3, SGN3 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human COPS3 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, RD, Mouse testis, Mouse brain, Mouse kidney |
| Immunogen: | A synthesized peptide derived from human COPS3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8533 |
| Uniprot: | Q9UNS2 |
| Calculated MW: | 48kDa |
| Observed MW: | 44KDa |
| UniProt Protein Function: | COPS3: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN3 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: nucleoplasm; signalosome; cytoplasm; nucleus Molecular Function:protein binding Biological Process: ubiquitin-dependent protein catabolic process; response to light stimulus; cullin deneddylation; in utero embryonic development; signal transduction |
| NCBI Summary: | The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q9UNS2 |
| NCBI GenInfo Identifier: | 55976621 |
| NCBI Gene ID: | 8533 |
| NCBI Accession: | Q9UNS2.3 |
| UniProt Secondary Accession: | Q9UNS2,O43191, Q7LDR6, B2R683, B4DY81, |
| UniProt Related Accession: | Q9UNS2 |
| Molecular Weight: | 423 |
| NCBI Full Name: | COP9 signalosome complex subunit 3 |
| NCBI Synonym Full Names: | COP9 signalosome subunit 3 |
| NCBI Official Symbol: | COPS3Â Â |
| NCBI Official Synonym Symbols: | CSN3; SGN3Â Â |
| NCBI Protein Information: | COP9 signalosome complex subunit 3; signalosome subunit 3; COP9 complex subunit 3; JAB1-containing signalosome subunit 3; COP9 constitutive photomorphogenic homolog subunit 3 |
| UniProt Protein Name: | COP9 signalosome complex subunit 3 |
| UniProt Synonym Protein Names: | JAB1-containing signalosome subunit 3 |
| UniProt Gene Name: | COPS3Â Â |
| UniProt Entry Name: | CSN3_HUMAN |
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