Anti-CSK Antibody (CAB0666)
- SKU:
- CAB0666
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Product Name: | CSK Rabbit mAb |
| Product Code: | CAB0666 |
| Size: | 20uL, 50uL, 100uL |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CSK |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, Jurkat, Raji, C6, Mouse spleen, Mouse thymus, Rat lung, Rat spleen |
| Immunogen: | A synthesized peptide derived from human CSK |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1445 |
| Uniprot: | P41240 |
| Calculated MW: | 50kDa |
| Observed MW: | 48kDa |
| UniProt Protein Function: | CSK: a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development. |
| UniProt Protein Details: | Protein type:Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Csk family Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; plasma membrane Molecular Function:identical protein binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; protein binding; protein C-terminus binding; protein-tyrosine kinase activity; receptor binding Biological Process: cell differentiation; cell migration; central nervous system development; epidermal growth factor receptor signaling pathway; innate immune response; negative regulation of Golgi to plasma membrane protein transport; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway |
| UniProt Code: | P41240 |
| NCBI GenInfo Identifier: | 729887 |
| NCBI Gene ID: | 1445 |
| NCBI Accession: | P41240.1 |
| UniProt Secondary Accession: | P41240,Q2M3N2, Q6FGZ6, |
| UniProt Related Accession: | P41240 |
| Molecular Weight: | 50,704 Da |
| NCBI Full Name: | Tyrosine-protein kinase CSK |
| NCBI Synonym Full Names: | c-src tyrosine kinase |
| NCBI Official Symbol: | CSKÂ Â |
| NCBI Protein Information: | tyrosine-protein kinase CSK |
| UniProt Protein Name: | Tyrosine-protein kinase CSK |
| UniProt Synonym Protein Names: | C-Src kinase; Protein-tyrosine kinase CYL |
| Protein Family: | Chloroplast sensor kinase |
| UniProt Gene Name: | CSKÂ Â |
| UniProt Entry Name: | CSK_HUMAN |
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