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Anti-eIF2B epsilon (EIF2B5) Antibody (CAB8670)

SKU:
CAB8670
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CACH
CLE
EIF-2B
EIF2Bepsilon
LVWM
Research Area:
Metabolism
€139 - €419
Frequently bought together:

Description

Product Name:eIF2B epsilon (EIF2B5) Rabbit mAb
Product Code:CAB8670
Size:20uL, 50uL, 100uL
Synonyms:CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human eIF2B epsilon (EIF2B5) (EIF2B5)
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HT-29, U-87MG
Immunogen:A synthesized peptide derived from human eIF2B epsilon (EIF2B5) (EIF2B5)
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8893
Uniprot:Q13144
Calculated MW:80kDa
Observed MW:80kDa
UniProt Protein Function:eIF2B-epsilon: eukaryotic translation initiation factor 2B, subunit 5. A translational regulatory protein that functions in the early steps of protein synthesis by catalyzing the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Mutation in EIF2B5 causes childhood ataxia with central nervous system hypomyelination/ vanishing white matter leukodystrophy.
UniProt Protein Details:

Protein type:Translation; Translation initiation

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex; nucleus

Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; translation initiation factor activity; translation initiation factor binding

Biological Process: astrocyte development; astrocyte differentiation; myelination; negative regulation of translation initiation in response to stress; oligodendrocyte development; ovarian follicle development; positive regulation of translational initiation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation

Disease: Leukoencephalopathy With Vanishing White Matter

NCBI Summary:This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]
UniProt Code:Q13144
NCBI GenInfo Identifier:160359049
NCBI Gene ID:8893
NCBI Accession:Q13144.3
UniProt Secondary Accession:Q13144,Q541Z1, Q96D04,
UniProt Related Accession:Q13144
Molecular Weight:80kDa
NCBI Full Name:Translation initiation factor eIF-2B subunit epsilon
NCBI Synonym Full Names:eukaryotic translation initiation factor 2B subunit epsilon
NCBI Official Symbol:EIF2B5  
NCBI Official Synonym Symbols:CLE; CACH; LVWM; EIF-2B; EIF2Bepsilon  
NCBI Protein Information:translation initiation factor eIF-2B subunit epsilon
UniProt Protein Name:Translation initiation factor eIF-2B subunit epsilon
UniProt Synonym Protein Names:eIF-2B GDP-GTP exchange factor subunit epsilon
Protein Family:Translation initiation factor
UniProt Gene Name:EIF2B5  

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