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Anti-ENTPD5 Antibody (CAB19642)

SKU:
CAB19642
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CD39L4
NTPDase-5
PCPH
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:ENTPD5 Rabbit mAb
Product Code:CAB19642
Size:20uL, 50uL, 100uL
Synonyms:CD39L4, NTPDase-5, PCPH
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ENTPD5
Applications:WB
Recommended Dilutions:WB 1:1000 - 1:3000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Rat liver, Rat kidney
Immunogen:A synthesized peptide derived from human ENTPD5
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:957
Uniprot:O75356
Calculated MW:47kDa
Observed MW:48KDa
UniProt Protein Function:ENTPD5: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. Belongs to the GDA1/CD39 NTPase family.
UniProt Protein Details:

Protein type:Hydrolase; Nucleotide Metabolism - pyrimidine; Oncoprotein; EC 3.6.1.6; EC 3.6.1.42; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: endoplasmic reticulum

Molecular Function:guanosine-diphosphatase activity; protein binding; uridine-diphosphatase activity

Biological Process: 'de novo' posttranslational protein folding; ATP metabolic process; cell growth; cell proliferation; positive regulation of glycolysis; protein amino acid N-linked glycosylation; regulation of phosphoinositide 3-kinase cascade

NCBI Summary:The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]
UniProt Code:O75356
NCBI GenInfo Identifier:18202142
NCBI Gene ID:957
NCBI Accession:O75356.1
UniProt Secondary Accession:O75356,Q96RX0, A1L4C5,
UniProt Related Accession:O75356
Molecular Weight:47,517 Da
NCBI Full Name:Ectonucleoside triphosphate diphosphohydrolase 5
NCBI Synonym Full Names:ectonucleoside triphosphate diphosphohydrolase 5
NCBI Official Symbol:ENTPD5  
NCBI Official Synonym Symbols:PCPH; CD39L4; NTPDase-5  
NCBI Protein Information:ectonucleoside triphosphate diphosphohydrolase 5
UniProt Protein Name:Ectonucleoside triphosphate diphosphohydrolase 5
UniProt Synonym Protein Names:CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5 (EC:3.6.1.42); GDPase ENTPD5; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5
Protein Family:Ectonucleoside triphosphate diphosphohydrolase
UniProt Gene Name:ENTPD5  
UniProt Entry Name:ENTP5_HUMAN

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