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Anti-IL2 Antibody (CAB20224)

SKU:
CAB20224
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IL2
IL-2
TCGF
lymphokine
Research Area:
Immunology
$395 - $503
Frequently bought together:

Description

Product Name:IL2 Rabbit mAb
Product Code:CAB20224
Size:50uL, 100uL
Synonyms:IL2, IL-2, TCGF, lymphokine
Applications:WB, FC, ELISA
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human IL2.
Applications:WB, FC, ELISA
Recommended Dilutions:Elisa 1:500 - 1:2000 WB 1:500 - 1:2000 FC 1:50 - 1:200
Reactivity:Human
Positive Samples:293T, Jurkat
Immunogen:Recombinant protein of human IL2.
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% Thimerosal, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3558
Uniprot:P60568
Cellular Location:Secreted
Calculated MW:17kDa
Observed MW:14KDa/15KDa
UniProt Protein Function:IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.
UniProt Protein Details:

Protein type:Cytokine; Secreted; Secreted, signal peptide; Oncoprotein

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular space; extracellular region

Molecular Function:growth factor activity; interleukin-2 receptor binding; kinase activator activity; cytokine activity; carbohydrate binding; glycosphingolipid binding; kappa-type opioid receptor binding

Biological Process: positive regulation of isotype switching to IgG isotypes; negative regulation of heart contraction; natural killer cell activation; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; elevation of cytosolic calcium ion concentration; negative regulation of protein amino acid phosphorylation; cell-cell signaling; protein kinase C activation; positive regulation of cell proliferation; positive regulation of B cell proliferation; cell adhesion; T cell differentiation; positive regulation of interleukin-17 production; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of cell growth; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; immune response; negative regulation of B cell apoptosis; positive regulation of inflammatory response; negative regulation of apoptosis

NCBI Summary:The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
UniProt Code:P60568
NCBI GenInfo Identifier:45593462
NCBI Gene ID:3558
NCBI Accession:P60568.1
UniProt Secondary Accession:P60568,P01585,
UniProt Related Accession:P60568
Molecular Weight:153
NCBI Full Name:Interleukin-2
NCBI Synonym Full Names:interleukin 2
NCBI Official Symbol:IL2  
NCBI Official Synonym Symbols:IL-2; TCGF; lymphokine  
NCBI Protein Information:interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion
UniProt Protein Name:Interleukin-2
UniProt Synonym Protein Names:T-cell growth factor; TCGF; INN: Aldesleukin
Protein Family:Interleukin
UniProt Gene Name:IL2  
UniProt Entry Name:IL2_HUMAN

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