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Anti-INTS8 Antibody (CAB20513)

SKU:
CAB20513
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
C8orf52
INT8
INTS8
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:INTS8 Rabbit pAb
Product Code:CAB20513
Size:50uL, 100uL
Synonyms:C8orf52, INT8, INTS8
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human INTS8.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant protein of human INTS8.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:AIRT IVQS SFPV KQAK PGPP QLSV MNQM QQEK ELTE NILK VLKE QAAD SILV LEAA LKLN KDLY VHTM RTLD LLAM EPGM VNGE TESS TAGL KVKT EEMQ C
Gene ID:55656
Uniprot:Q75QN2
Calculated MW:113kDa
Observed MW:90-115KDa
UniProt Protein Function:INTS8: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: integrator complex; nucleoplasm

Molecular Function:protein binding

Biological Process: snRNA processing; snRNA transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
UniProt Code:Q75QN2
NCBI GenInfo Identifier:70608109
NCBI Gene ID:55656
NCBI Accession:NP_060334.2
UniProt Secondary Accession:Q75QN2,Q5RKZ3, Q6P1R5, Q7Z314, Q9NVS6, Q9NWY7, B2RN92
UniProt Related Accession:Q75QN2
Molecular Weight:111,116 Da
NCBI Full Name:integrator complex subunit 8
NCBI Synonym Full Names:integrator complex subunit 8
NCBI Official Symbol:INTS8  
NCBI Official Synonym Symbols:INT8; C8orf52  
NCBI Protein Information:integrator complex subunit 8
UniProt Protein Name:Integrator complex subunit 8
UniProt Synonym Protein Names:Protein kaonashi-1
UniProt Gene Name:INTS8  

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