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Anti-IQGAP1 Antibody (CAB9765)

SKU:
CAB9765
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HUMORFA01
SAR1
p195
Research Area:
Immunology
€139 - €419
Frequently bought together:

Description

Product Name:IQGAP1 Rabbit mAb
Product Code:CAB9765
Size:20uL, 50uL, 100uL
Synonyms:HUMORFA01, SAR1, p195
Applications:WB, IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human IQGAP1
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:U-87MG, Mouse lung
Immunogen:A synthesized peptide derived from human IQGAP1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8826
Uniprot:P46940
Calculated MW:195kDa
Observed MW:195kDa
UniProt Protein Function:IQGAP1: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: actin cytoskeleton; actin filament; axon; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; growth cone; microtubule; microtubule cytoskeleton; midbody; neuron projection; plasma membrane; ruffle

Molecular Function:calcium ion binding; calmodulin binding; GTPase inhibitor activity; phosphatidylinositol-3,4,5-triphosphate binding; protein binding; protein domain specific binding; protein kinase binding; protein phosphatase binding; protein serine/threonine kinase activator activity

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of protein kinase activity; signal transduction

NCBI Summary:This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
UniProt Code:P46940
NCBI GenInfo Identifier:1170586
NCBI Gene ID:8826
NCBI Accession:P46940.1
UniProt Secondary Accession:P46940,A7MBM3,
UniProt Related Accession:P46940
Molecular Weight:189,252 Da
NCBI Full Name:Ras GTPase-activating-like protein IQGAP1
NCBI Synonym Full Names:IQ motif containing GTPase activating protein 1
NCBI Official Symbol:IQGAP1  
NCBI Official Synonym Symbols:SAR1; p195; HUMORFA01  
NCBI Protein Information:ras GTPase-activating-like protein IQGAP1
UniProt Protein Name:Ras GTPase-activating-like protein IQGAP1
UniProt Synonym Protein Names:p195
Protein Family:Ras GTPase-activating-like protein
UniProt Gene Name:IQGAP1  
UniProt Entry Name:IQGA1_HUMAN

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