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Anti-MDH1 Antibody (CAB9673)

SKU:
CAB9673
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HEL-S-32
MDH-s
MDHA
MGC:1375
MOR2
Research Area:
Metabolism
$167 - $503
Frequently bought together:

Description

Product Name:MDH1 Rabbit mAb
Product Code:CAB9673
Size:20uL, 50uL, 100uL
Synonyms:HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MDH1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Jurkat, U-251MG, Mouse liver, Mouse brain, Rat kidney, Rat heart
Immunogen:A synthesized peptide derived from human MDH1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4190
Uniprot:P40925
Calculated MW:36kDa
Observed MW:36kDa
UniProt Protein Function:MDH1: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
UniProt Protein Details:

Protein type:EC 1.1.1.96; Carbohydrate Metabolism - pyruvate; Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.37; Carbohydrate Metabolism - glyoxylate and dicarboxylate

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: centrosome; extracellular space; mitochondrion; cytoplasm; cytosol

Molecular Function:malic enzyme activity; L-malate dehydrogenase activity; diiodophenylpyruvate reductase activity; NAD binding

Biological Process: malate metabolic process; oxaloacetate metabolic process; NADH metabolic process; tricarboxylic acid cycle; carbohydrate metabolic process; glucose metabolic process; cellular carbohydrate metabolic process; pathogenesis; gluconeogenesis

NCBI Summary:This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]
UniProt Code:P40925
NCBI GenInfo Identifier:1708967
NCBI Gene ID:4190
NCBI Accession:P40925.4
UniProt Related Accession:P40925
Molecular Weight:~ 36kDa
NCBI Full Name:Malate dehydrogenase, cytoplasmic
NCBI Synonym Full Names:malate dehydrogenase 1
NCBI Official Symbol:MDH1  
NCBI Official Synonym Symbols:MDHA; MOR2; MDH-s; HEL-S-32; MGC:1375  
NCBI Protein Information:malate dehydrogenase, cytoplasmic; malate dehydrogenase, peroxisomal
UniProt Protein Name:Malate dehydrogenase, cytoplasmic
UniProt Synonym Protein Names:Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase (EC:1.1.1.96)
Protein Family:Malate dehydrogenase
UniProt Gene Name:MDH1  
UniProt Entry Name:MDHC_HUMAN

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