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Anti-MED26 Antibody (CAB20500)

SKU:
CAB20500
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CRSP7
CRSP70
€139 - €419
Frequently bought together:

Description

Product Name:MED26 Rabbit pAb
Product Code:CAB20500
Size:50uL, 100uL
Synonyms:CRSP7, CRSP70
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human MED26.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Raji, Mouse brain, Mouse spinal cord
Immunogen:Recombinant protein of human MED26.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9441
Uniprot:O95402
Calculated MW:65kDa
Observed MW:70KDa
UniProt Protein Function:MED26: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 26 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: nucleoplasm; Srb-mediator complex

Molecular Function:protein binding; transcription coactivator activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter

NCBI Summary:The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]
UniProt Code:O95402
NCBI GenInfo Identifier:158931130
NCBI Gene ID:9441
NCBI Accession:O95402.2
UniProt Secondary Accession:O95402,Q0VGB6, A1A4S3,
UniProt Related Accession:O95402
Molecular Weight:10,359 Da
NCBI Full Name:Mediator of RNA polymerase II transcription subunit 26
NCBI Synonym Full Names:mediator complex subunit 26
NCBI Official Symbol:MED26  
NCBI Official Synonym Symbols:CRSP7; CRSP70  
NCBI Protein Information:mediator of RNA polymerase II transcription subunit 26
UniProt Protein Name:Mediator of RNA polymerase II transcription subunit 26
UniProt Synonym Protein Names:Activator-recruited cofactor 70 kDa component; ARC70; Cofactor required for Sp1 transcriptional activation subunit 7; CRSP complex subunit 7; Mediator complex subunit 26; Transcriptional coactivator CRSP70
Protein Family:Mediator of RNA polymerase II transcription
UniProt Gene Name:MED26  
UniProt Entry Name:MED26_HUMAN

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