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Anti-RPB3/POLR2C Antibody (CAB9744)

SKU:
CAB9744
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RPB3
RPB31
hRPB33
hsRPB3
Research Area:
Epigenetics and Nuclear Signaling
€139 - €419
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Description

Product Name:RPB3/POLR2C Rabbit mAb
Product Code:CAB9744
Size:20uL, 50uL, 100uL
Synonyms:RPB3, RPB31, hRPB33, hsRPB3
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human RPB3/POLR2C
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Mouse kidney, Rat lung, Rat brain, Rat spleen
Immunogen:A synthesized peptide derived from human RPB3/POLR2C
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5432
Uniprot:P19387
Calculated MW:33kDa
Observed MW:35KDa
UniProt Protein Function:POLR2C: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family.
UniProt Protein Details:

Protein type:DNA-binding; Nucleotide Metabolism - purine; Transcription initiation complex; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 16q13-q21

Cellular Component: nucleoplasm; microtubule cytoskeleton; cytoplasm; DNA-directed RNA polymerase II, core complex; nucleus

Molecular Function:protein dimerization activity; DNA binding

Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; transcription initiation from RNA polymerase II promoter; mRNA capping; viral reproduction; positive regulation of viral transcription; nucleotide-excision repair; somatic stem cell maintenance; transcription-coupled nucleotide-excision repair; RNA splicing; RNA elongation from RNA polymerase II promoter; gene expression; DNA repair

NCBI Summary:This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]
UniProt Code:P19387
NCBI GenInfo Identifier:3915850
NCBI Gene ID:5432
NCBI Accession:P19387.2
UniProt Related Accession:P19387
Molecular Weight:
NCBI Full Name:DNA-directed RNA polymerase II subunit RPB3
NCBI Synonym Full Names:RNA polymerase II subunit C
NCBI Official Symbol:POLR2C  
NCBI Official Synonym Symbols:RPB3; RPB31; hRPB33; hsRPB3  
NCBI Protein Information:DNA-directed RNA polymerase II subunit RPB3
UniProt Protein Name:DNA-directed RNA polymerase II subunit RPB3
UniProt Synonym Protein Names:DNA-directed RNA polymerase II 33 kDa polypeptide; RPB33; DNA-directed RNA polymerase II subunit C; RPB31
Protein Family:DNA-directed RNA polymerase
UniProt Gene Name:POLR2C  
UniProt Entry Name:RPB3_HUMAN

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