The SynGAP Monoclonal Antibody (CAB19581) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, derived from mouse hybridoma cells, is highly specific to human samples and is suitable for use in immunohistochemistry and immunofluorescence experiments.SynGAP is a key player in neuronal signaling pathways, influencing processes such as synaptic plasticity, learning, and memory. Dysregulation of SynGAP expression has been implicated in neurodevelopmental disorders such as intellectual disability and epilepsy, making it a compelling target for research in neuroscience and neurology.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
SynGAP Monoclonal Antibody
SKU:
CAB19581
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC2183
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
8831
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using SynGAP Rabbit mAb (CAB19581) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
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