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Anti-TAB3 Antibody (CAB19824)

SKU:
CAB19824
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MAP3K7IP3
NAP1
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:TAB3 Rabbit mAb
Product Code:CAB19824
Size:20uL, 50uL, 100uL
Synonyms:MAP3K7IP3, NAP1
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human TAB3
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:HeLa, 293T, HepG2, Mouse liver
Immunogen:A synthesized peptide derived from human TAB3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:257397
Uniprot:Q8N5C8
Calculated MW:90kDa
Observed MW:100KDa
UniProt Protein Function:TAB3: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: Xp21.2

Cellular Component: cytoplasm; cytosol; endosome membrane; nucleoplasm; plasma membrane

Molecular Function:protein binding

Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; I-kappaB kinase/NF-kappaB cascade; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; negative regulation of autophagy; stimulatory C-type lectin receptor signaling pathway

NCBI Summary:The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q8N5C8
NCBI GenInfo Identifier:229462756
NCBI Gene ID:257397
NCBI Accession:Q8N5C8.2
UniProt Secondary Accession:Q8N5C8,Q6VQR0, A6NDD9,
UniProt Related Accession:Q8N5C8
Molecular Weight:75,599 Da
NCBI Full Name:TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
NCBI Synonym Full Names:TGF-beta activated kinase 1/MAP3K7 binding protein 3
NCBI Official Symbol:TAB3  
NCBI Official Synonym Symbols:NAP1; MAP3K7IP3  
NCBI Protein Information:TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
UniProt Protein Name:TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
UniProt Synonym Protein Names:Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TAB-3; TGF-beta-activated kinase 1-binding protein 3
Protein Family:TGF-beta-activated kinase 1 and MAP3K7-binding protein
UniProt Gene Name:TAB3  
UniProt Entry Name:TAB3_HUMAN

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