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Anti-ULK3 Antibody (CAB5959)

SKU:
CAB5959
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Autophagy
€139 - €419
Frequently bought together:

Description

Product Name:ULK3 Rabbit mAb
Product Code:CAB5959
Size:20uL, 50uL, 100uL
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ULK3
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Immunogen:A synthesized peptide derived from human ULK3
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:25989
Uniprot:Q6PHR2
Calculated MW:53kDa
UniProt Protein Function:ULK3: Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Other group; ULK family

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: cytoplasm

Molecular Function:protein binding; protein serine/threonine kinase activity

Biological Process: autophagy; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway; protein amino acid autophosphorylation

UniProt Code:Q6PHR2
NCBI GenInfo Identifier:259016166
NCBI Gene ID:25989
NCBI Accession:Q6PHR2.2
UniProt Secondary Accession:Q6PHR2,Q9NPN5, Q9UFS4, B2RXK3, B4DFT0, B4DRQ7, D3DW68
UniProt Related Accession:Q6PHR2
Molecular Weight:54,997 Da
NCBI Full Name:Serine/threonine-protein kinase ULK3
NCBI Synonym Full Names:unc-51 like kinase 3
NCBI Official Symbol:ULK3  
NCBI Protein Information:serine/threonine-protein kinase ULK3
UniProt Protein Name:Serine/threonine-protein kinase ULK3
UniProt Synonym Protein Names:Unc-51-like kinase 3
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:ULK3  
UniProt Entry Name:ULK3_HUMAN

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