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APC Anti-Human CD20 Antibody [BCA/B20] (AGEL2814)

Datasheet MSDS
SKU AGEL2814
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG2a, κ
Clone BCA/B20
Conjugation APC
€73 - €285

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Description

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APC Anti-Human CD20 Antibody [BCA/B20]

The APC Anti-Human CD20 Antibody (BCA-B20) is a powerful tool designed for research involving the CD20 protein, a cell surface molecule predominantly expressed on B-cells. This antibody, conjugated to Allophycocyanin (APC), offers high sensitivity and specificity in detecting human CD20 in various sample types, making it ideal for use in flow cytometry and immunofluorescence applications.CD20 plays a crucial role in B-cell development and is a key target in the treatment of B-cell malignancies such as non-Hodgkin's lymphoma and chronic lymphocytic leukemia.

The APC Anti-Human CD20 Antibody enables researchers to accurately identify and analyze CD20-expressing B-cells, facilitating studies on B-cell biology, immunology, and disease pathogenesis.With its exceptional reactivity and validated performance in experimental settings, the APC Anti-Human CD20 Antibody (BCA-B20) is a valuable tool for advancing research in immunology, oncology, and therapeutic development related to B-cell disorders.

Product Title:APC Anti-Human CD20 Antibody [BCA/B20]
SKU:AGEL2814
Size:20 Tests, 100 Tests, 200 Tests
Clone No:BCA/B20
Synonyms:B-lymphocyte antigen CD20;MS4A1;B-lymphocyte surface antigen B1;Bp35;Leukocyte surface antigen Leu-16;Membrane-spanning 4-domains subfamily A member 1;MS4A1;CD20;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:APC Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P11836
Gene ID:931
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
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