Description
Apoptosis - Intrinsic (Mitochondrial) Antibody Sampler Pack (ABSP001)
The Apoptosis - Intrinsic (Mitochondrial) Antibody Sampler Pack from Assay Genie brings together 8 rigorously validated antibodies covering the key nodes of this pathway in a convenient 20µL trial format. It is designed to let researchers interrogate an entire signalling axis in a single, cost-effective pack, then scale up to full-size formats for the targets that matter most to their work.
| Pack Name: | Apoptosis - Intrinsic (Mitochondrial) Antibody Sampler Pack |
| SKU: | ABSP001 |
| Research Area: | Cancer |
| Targets Included: | 8 |
| Format: | 8 × 20µL |
| Targets: | Bcl-2, Bax, Bak, Bcl-xL, Bad, Cytochrome c, Caspase-9, Cleaved Caspase-3 |
| Target | Antibody | SKU | Host | Reactivity | Applications | Size |
|---|---|---|---|---|---|---|
| Bcl-2 | Anti-Bcl-2 Monoclonal Antibody | CAB20777-20 | Mouse | Human, Mouse, Rat | WB IF/ICC ELISA | 20µL |
| Bax | Anti-Bax [ARC5006-10] Monoclonal Antibody -Knockout Validated | CAB20227-20 | Rabbit | Human, Mouse, Rat | WB IF/ICC IP ELISA | 20µL |
| Bak | Anti-Bak Monoclonal Antibody | CAB23523-20 | Rabbit | Human, Monkey | WB IHC-P ELISA | 20µL |
| Bcl-xL | Anti-Bcl-XL Polyclonal Antibody -Knockout Validated | CAB22241-20 | Rabbit | Human, Mouse, Rat | WB ELISA | 20µL |
| Bad | Anti-Bad Monoclonal Antibody | CAB19595-20 | Rabbit | Human, Mouse, Rat | WB IHC-P ELISA | 20µL |
| Cytochrome c | Anti-Cytochrome C Monoclonal Antibody -Knockout Validated | CAB4912-20 | Rabbit | Human, Mouse, Rat | WB IHC-P ELISA | 20µL |
| Caspase-9 | Anti-Caspase-9 Antibody -Knockout Validated | CAB0281-20 | Rabbit | Human, Mouse, Rat | WB IHC-P IF/ICC ELISA | 20µL |
| Cleaved Caspase-3 | Anti-Caspase-3 p12 [ARC0143] Monoclonal Antibody | CAB19664-20 | Rabbit | Human, Mouse, Rat | WB IHC-P IF/ICC ELISA | 20µL |
The intrinsic apoptotic pathway is governed by the balance of pro- and anti-apoptotic BCL-2 family proteins at the mitochondrial membrane. Pro-apoptotic signals shift this balance toward BAX/BAK oligomerisation, mitochondrial outer membrane permeabilisation and cytochrome c release, triggering APAF-1/caspase-9 apoptosome assembly and downstream caspase-3 activation.
| Pack Format: | 8 antibodies, 20µL each (trial size) |
| Storage: | Store at -20°C |
| Shelf Life: | 12 months |
| Shipping: | Gel pack |
Every antibody in this sampler pack is also available individually in full 100µL size for follow-on experiments and assay scale-up.
