Anti-Cytochrome C [KO Validated] Antibody (CAB4912)
- SKU:
- CAB4912
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CYC
- HCS
- THC4
- Research Area:
- Cell Death
Description
| Product Name: | [KO Validated] Cytochrome C Rabbit mAb |
| Product Code: | CAB4912 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CYC, HCS, THC4 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Cytochrome C |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, Mouse brain, Mouse kidney, Mouse heart, Rat brain, Rat kidney |
| Immunogen: | A synthesized peptide derived from human Cytochrome C |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 54205 |
| Uniprot: | P99999 |
| Cellular Location: | Mitochondrion intermembrane space |
| Calculated MW: | 15kDa |
| Observed MW: | 14KDa |
| UniProt Protein Function: | CYCS: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family. |
| UniProt Protein Details: | Protein type:Apoptosis; Oxidoreductase; Mitochondrial; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 7p15.3 Cellular Component: cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleus; protein phosphatase type 2A complex Molecular Function:electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; heme binding; protein binding; protein serine/threonine phosphatase activity Biological Process: caspase activation via cytochrome c; cellular respiration; mitochondrial electron transport, cytochrome c to oxygen; mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrion organization and biogenesis; response to reactive oxygen species Disease: Thrombocytopenia 4 |
| NCBI Summary: | This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010] |
| UniProt Code: | P99999 |
| NCBI GenInfo Identifier: | 42560196 |
| NCBI Gene ID: | 54205 |
| NCBI Accession: | P99999.2 |
| UniProt Secondary Accession: | P99999,P00001, Q6NUR2, Q6NX69, Q96BV4, A4D166, B2R4I1 |
| UniProt Related Accession: | P99999 |
| Molecular Weight: | 11,749 Da |
| NCBI Full Name: | Cytochrome c |
| NCBI Synonym Full Names: | cytochrome c, somatic |
| NCBI Official Symbol: | CYCSÂ Â |
| NCBI Official Synonym Symbols: | CYC; HCS; THC4Â Â |
| NCBI Protein Information: | cytochrome c |
| UniProt Protein Name: | Cytochrome c |
| Protein Family: | Cytochrome |
| UniProt Gene Name: | CYCSÂ Â |
| UniProt Entry Name: | CYC_HUMAN |
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