The Biotinylated Anti-41BB Antibody (HDLA029) is a powerful tool for studying the 41BB protein, a key regulator of immune responses and immune cell activation. This antibody, produced and validated for use in various applications including immunohistochemistry and flow cytometry, allows for precise detection and analysis of 41BB expression in a variety of cell types.41BB, also known as CD137, is a co-stimulatory molecule predominantly expressed on activated T cells and plays a crucial role in regulating T cell activation, proliferation, and survival. Its importance in modulating immune responses makes it a promising target for immunotherapy in diseases such as cancer, infectious diseases, and autoimmune disorders.
By understanding the function and expression of 41BB, researchers can develop novel therapeutic strategies that enhance immune responses or suppress aberrant immune activation for improved clinical outcomes.The Biotinylated Anti-41BB Antibody (HDLA029) offers high specificity and sensitivity, making it an indispensable tool for investigating the role of 41BB in immune regulation and disease pathogenesis. Whether studying basic immune cell biology or developing new immunotherapies, this antibody provides valuable insights into the complex mechanisms that underlie immune responses and can aid in the discovery of novel treatment approaches.
Product Code:
HDLA029
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM67
Synonyms:
TNFRSF9, 4-1BB, CD137, CDw137, ILA
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
