The Biotinylated Anti-CTLA4 Antibody (HDLA016) is a valuable tool for researchers studying the role of CTLA4 in immune regulation. This antibody, produced and validated by Assay Genie, is compatible with various applications such as Western blot and immunohistochemistry, allowing for precise detection and analysis of CTLA4 protein expression in human samples.CTLA4, also known as cytotoxic T-lymphocyte-associated protein 4, is a key regulator of T cell activation and immune response. By binding to CTLA4, this antibody enables researchers to study the function and expression of this critical protein in immunology research and cancer studies.
Understanding the role of CTLA4 in immune regulation is essential for developing targeted therapies for diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. The Biotinylated Anti-CTLA4 Antibody (HDLA016) from Assay Genie provides researchers with a reliable tool to advance their studies and uncover new insights into immune modulation and disease pathogenesis.
Product Code:
HDLA016
Size:
100 µg
Clonality:
Monoclonal
Clone:
DM51
Synonyms:
CTLA4, CD152
Applications:
ELISA, Flow Cyt
Recommended Dilution:
ELISA 1:5000-10000; Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit IgG
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
