Calnexin-CT Antibody is a rabbit polyclonal antibody directed against Calnexin-CT, offered by Assay Genie for research applications. Reported applications include WB, ICC/IF and IHC. Reported reactivity: Human, Mouse, Rat, Bovine, Monkey, Chicken, Dog, Guinea Pig (Cavia porcellus), Hamster, Pig, Avian, Quail, Rabbit, Sheep, Fruit Fly (Drosophila melanogaster) and African clawed frog (Xenopus laevis). Purified by Protein A.
Calnexin is a ~90 kDa integral membrane protein of the endoplasmic reticulum (ER), also known as IP90, p88, or p90. Structurally, it comprises a large N-terminal calcium-binding luminal domain (~50 kDa), a single transmembrane helix, and a short, acidic cytoplasmic tail (CT). Unlike many ER-resident proteins that rely on a C-terminal KDEL motif for retention, Calnexin is retained in the ER via positively charged residues in its cytosolic tail. Functionally, Calnexin is a central component of the ER quality control system. It acts as a molecular chaperone, facilitating the proper folding and assembly of nascent glycoproteins. In concert with calreticulin, Calnexin binds to monoglucosylated N-linked glycans on folding intermediates, ensuring fidelity in glycoprotein maturation. It also interacts with key immune molecules, including MHC class I heavy chains, T cell receptor subunits, and B cell immunoglobulins. In neuroscience, Calnexin-CT is gaining attention for its role in neurodegenerative disease. ER stress and impaired protein folding are hallmarks of disorders such as Alzheimer’s, Parkinson’s, and ALS. Dysregulation of Calnexin function can exacerbate proteostasis imbalance, leading to accumulation of misfolded proteins and neuronal dysfunction. Given its dual role in protein folding and ER homeostasis, Calnexin—particularly its cytoplasmic tail—represents a promising target for therapeutic strategies aimed at restoring proteostasis in neurodegenerative diseases. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 200 µl. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
Calnexin-CT Antibody
Product SKU:
STPA00007
Size:
200 µl
Target:
Calnexin-CT
Host Species:
Rabbit
Antibody Type:
Polyclonal
Research Areas:
Cell Signaling, Tags and Cell Markers, Organelle Markers
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Calnexin, CALX_HUMAN, CANX, CNX, FLJ26570, IP90, p88, p90, Histocompatibility complex class I antigen binding protein p88, Major histocompatibility complex class I antigen-binding protein p88
References:
1. Rajagopalan S., Xu Y., and Brenner M.B. (1994) Science 263(5145): 387-90. 2. Tjoelker L.W., et al. (1994) Biochemistry 33: 3229. 3. Schrag J. et al. (2001) Molecular Cell 8(3): 633-644. 4. Janiszewski M. (2005) J. Biol Chem. 280(49): 40813-40819. 5. Elagoz A., Callejo M., Armstrong J., and Rokeach L. A. (1999) J. Cell Sci. 112: 4449-4460. 6. Otteken A. and Moss B. (1996) J Bio Chem. 271(1): 97-103. 7. Galvin K. et al. (1992) Proc Natl Acad Sci USA. 89(18): 8452-6.
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