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CD4 Rabbit Polyclonal Antibody (CAB0362)

SKU:
CAB0362
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • Immunology Antibodies 1 Anti-CD4 Antibody CAB0362
  • Immunology Antibodies 1 Anti-CD4 Antibody CAB0362
  • Immunology Antibodies 1 Anti-CD4 Antibody CAB0362
  • Immunology Antibodies 1 Anti-CD4 Antibody CAB0362
$167 - $503
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Description

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Product Name:CD4 Rabbit Polyclonal Antibody
SKU:CAB0362
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 26-200 of human CD4 (NP_000607.1).
Sequence:KKVV LGKK GDTV ELTC TASQ KKSI QFHW KNSN QIKI LGNQ GSFL TKGP SKLN DRAD SRRS LWDQ GNFP LIIK NLKI EDSD TYIC EVED QKEE VQLL VFGL TANS DTHL LQGQ SLTL TLES PPGS SPSV QCRS PRGK NIQG GKTL SVSQ LELQ DSGT WTCT VLQN QKKV EFKI DIV
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:T4; IMD79; Leu-3; OKT4D; CD4mut; CD4
Positive Sample:U-937
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Single-pass type I membrane protein.
Calculated MW:51kDa
Observed MW:51kDa

This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Purification Method:Affinity purification
Gene ID:920
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from U-937 cells, using CD4 Rabbit pAb (CAB0362) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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