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Anti-CD69 Antibody (CAB2045)

SKU:
CAB2045
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 8 Anti-CD69 Antibody CAB2045
  • Cell Biology Antibodies 8 Anti-CD69 Antibody CAB2045
  • Cell Biology Antibodies 8 Anti-CD69 Antibody CAB2045
€139 - €419
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Description

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Antibody Name:Anti-CD69 Antibody
Antibody SKU:CAB2045
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 62-199 of human CD69 (NP_001772.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:U-937, Mouse lung, Mouse spleen, Rat lung, Rat spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 62-199 of human CD69 (NP_001772.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SVGQ YNCP GQYT FSMP SDSH VSSC SEDW VGYQ RKCY FIST VKRS WTSA QNAC SEHG ATLA VIDS EKDM NFLK RYAG REEH WVGL KKEP GHPW KWSN GKEF NNWF NVTG SDKC VFLK NTEV SSME CEKN LYWI CNKP YK
Gene ID:969
Uniprot:Q07108
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:22kDa
Observed MW:25-45KDa
Synonyms:CD69, AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
Background:This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets.
UniProt Protein Function:Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
UniProt Protein Details:

Subunit structure: Homodimer; disulfide-linked. Ref.6 Ref.7 Ref.8

Subcellular location: Membrane; Single-pass type II membrane protein.

Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.

Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

Post-translational modification: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.

Sequence similarities: Contains 1 C-type lectin domain.

NCBI Summary:This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
UniProt Code:Q07108
NCBI GenInfo Identifier:584906
NCBI Gene ID:969
NCBI Accession:Q07108.1
UniProt Related Accession:Q07108
Molecular Weight:22,559 Da
NCBI Full Name:Early activation antigen CD69
NCBI Synonym Full Names:CD69 molecule
NCBI Official Symbol:CD69  
NCBI Official Synonym Symbols:AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26  
NCBI Protein Information:early activation antigen CD69; leukocyte surface antigen Leu-23; early T-cell activation antigen p60; early lymphocyte activation antigen; activation inducer molecule (AIM/CD69); C-type lectin domain family 2, member C; CD69 antigen (p60, early T-cell act
UniProt Protein Name:Early activation antigen CD69
UniProt Synonym Protein Names:Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3
UniProt Gene Name:CD69  
UniProt Entry Name:CD69_HUMAN
Anti-CD69 Antibody (CAB2045)Western blot analysis of extracts of various cell lines, using CD69 antibody (CAB2045) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-CD69 Antibody (CAB2045)Immunofluorescence analysis of rat thymus using CD69 Rabbit pAb (CAB2045) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-CD69 Antibody (CAB2045)Immunofluorescence analysis of mouse thymus using CD69 Rabbit pAb (CAB2045) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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