Anti-CDC37 Antibody (CAB4582)
- SKU:
- CAB4582
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- P50CDC37
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Product Name: | CDC37 Rabbit mAb |
| Product Code: | CAB4582 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | P50CDC37 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human CDC37 |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, Jurkat, Mouse brain, Mouse spleen, Rat lung, Rat spleen |
| Immunogen: | A synthesized peptide derived from human CDC37 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11140 |
| Uniprot: | Q16543 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 44kDa |
| Observed MW: | 50KDa |
| UniProt Protein Function: | CDC37: a molecular chaperone that functions in cell signal transduction. Forms complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Also interacts with androgen receptor. It is thought to play a critical role in directing Hsp90 to its target kinases. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: protein complex; cytoplasm; cytosol Molecular Function:protein kinase B binding; protein binding; chaperone binding; heat shock protein binding; unfolded protein binding; mitogen-activated protein kinase kinase kinase binding; Hsp90 protein binding; kinase binding Biological Process: protein folding; protein stabilization; regulation of cyclin-dependent protein kinase activity; protein targeting |
| NCBI Summary: | The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16543 |
| NCBI GenInfo Identifier: | 21542000 |
| NCBI Gene ID: | 11140 |
| NCBI Accession: | Q16543.1 |
| UniProt Secondary Accession: | Q16543,Q53YA2, |
| UniProt Related Accession: | Q16543 |
| Molecular Weight: | 378 |
| NCBI Full Name: | Hsp90 co-chaperone Cdc37 |
| NCBI Synonym Full Names: | cell division cycle 37 |
| NCBI Official Symbol: | CDC37Â Â |
| NCBI Official Synonym Symbols: | P50CDC37Â Â |
| NCBI Protein Information: | hsp90 co-chaperone Cdc37; cell division cycle 37 homolog; CDC37 cell division cycle 37 homolog; hsp90 chaperone protein kinase-targeting subunit; CDC37 (cell division cycle 37, S. cerevisiae, homolog) |
| UniProt Protein Name: | Hsp90 co-chaperone Cdc37 |
| UniProt Synonym Protein Names: | Hsp90 chaperone protein kinase-targeting subunit; p50Cdc37Hsp90 co-chaperone Cdc37, N-terminally processed |
| Protein Family: | Hsp90 co-chaperone |
| UniProt Gene Name: | CDC37Â Â |
| UniProt Entry Name: | CDC37_HUMAN |
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