Anti-CGB7 Antibody (CAB8522)

Antibody Name:	Anti-CGB7 Antibody
Antibody SKU:	CAB8522
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 21-165 of human CGB7 (NP_149133.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:	Human, Mouse, Rat
Positive Samples:	293T, MCF7, Mouse ovary, Mouse testis

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 21-165 of human CGB7 (NP_149133.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	SREM LRPR CRPI NATL AVEK EGCP VCIT VNTT ICAG YCPT MTRV LQGV LPAL PQVV CNYR DVRF ESIR LPGC PRGV NPVV SYAV ALSC QCAL CRRS TTDC GGPK DHPL TCDD PRFQ ASSS SKAP PPSL PSPS RLPG PSDT PILP Q
Gene ID:	94027
Uniprot:	P0DN87
Cellular Location:	Secreted
Calculated MW:	18kDa
Observed MW:	18kDa

Synonyms:

CGB7, CG-beta-a, CGB6

Background:

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene.

UniProt Protein Function:	CGB7: Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha- subunit is identical to the pituitary gonadotropin hormones (LH, FSH and TSH). The beta-subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. {ECO:0000305}. Belongs to the glycoprotein hormones subunit beta family. {ECO:0000305}. Heterodimer of a common alpha chain identical to LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones and confer receptor and biological specificity. {ECO:0000305}
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 19q13.33 Biological Process: apoptosis; cell-cell signaling; female gamete generation; signal transduction
NCBI Summary:	This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P0DN87
NCBI GenInfo Identifier:	1027923600
NCBI Gene ID:	94027
NCBI Accession:	P0DN87.1
UniProt Secondary Accession:	P0DN87,P01233, Q13991, Q14000, Q3KPI3, Q3SY41, Q8WTT5 Q8WXL1, Q8WXL2, Q8WXL3, A1A5E0, B9ZVP5,
UniProt Related Accession:	P0DN87
Molecular Weight:	18kDa
NCBI Full Name:	Choriogonadotropin subunit beta 7
NCBI Synonym Full Names:	chorionic gonadotropin beta subunit 7
NCBI Official Symbol:	CGB7
NCBI Official Synonym Symbols:	CGB6; CG-beta-a
NCBI Protein Information:	choriogonadotropin subunit beta 7
UniProt Protein Name:	Choriogonadotropin subunit beta 7
Protein Family:	Choriogonadotropin
UniProt Gene Name:	CGB7

	Western blot analysis of extracts of various cell lines, using CGB7 antibody (CAB8522) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded mouse kidney using CGB7 antibody (CAB8522) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded rat kidney using CGB7 antibody (CAB8522) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using CGB7 antibody (CAB8522) at dilution of 1:100 (40x lens).

Antibodies

Anti-CGB7 Antibody (CAB12605)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)