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Anti-CLNS1A Antibody (CAB9739)

SKU:
CAB9739
Product Type:
Antibody
Applications:
WB
IHC
FC
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-CLNS1A Antibody
Antibody SKU:CAB9739
Antibody Size:100uL
Application:WB IHC FC
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic Peptide of human CLNS1A
Application:WB IHC FC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:20 - 1:50 FC 1:20 - 1:50
Reactivity:Human
Positive Samples:293T, DU145, Jurkat, HeLa
Immunogen:A synthetic Peptide of human CLNS1A
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1207
Uniprot:P54105
Cellular Location:Cytoplasm, Nucleus, cytoskeleton, cytosol
Calculated MW:26kDa
Observed MW:38kDa
Synonyms:CLNS1A, CLCI, CLNS1B, ICln
Background:This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family.
UniProt Protein Details:

Protein type:Channel, chloride

Chromosomal Location of Human Ortholog: 11q13.5-q14

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function:protein binding; protein heterodimerization activity

Biological Process: spliceosomal snRNP biogenesis

NCBI Summary:This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
UniProt Code:P54105
NCBI GenInfo Identifier:1708393
NCBI Gene ID:1207
NCBI Accession:P54105.1
UniProt Secondary Accession:P54105,Q0VDK6, Q9NRD2, Q9NRD3, B2RCS9,
UniProt Related Accession:P54105
Molecular Weight:26,215 Da
NCBI Full Name:Methylosome subunit pICln
NCBI Synonym Full Names:chloride nucleotide-sensitive channel 1A
NCBI Official Symbol:CLNS1A  
NCBI Official Synonym Symbols:CLCI; ICln; CLNS1B  
NCBI Protein Information:methylosome subunit pICln
UniProt Protein Name:Methylosome subunit pICln
UniProt Synonym Protein Names:Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln
UniProt Gene Name:CLNS1A  
UniProt Entry Name:ICLN_HUMAN
Anti-CLNS1A Polyclonal Antibody (CAB9739)Western blot analysis of extracts of various cell lines, using CLNS1A antibody (CAB9739) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.

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