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Anti-CSTF2 Antibody (CAB8116)

SKU:
CAB8116
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
$167 - $503
Frequently bought together:

Description

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Antibody Name:CSTF2 Rabbit Polyclonal Antibody
Antibody SKU:CAB8116
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CSTF2 (NP_001316.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Jurkat, HepG2, SW620, Mouse testis, Mouse thymus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human CSTF2 (NP_001316.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGL TVRD PAVD RSLR SVFV GNIP YEAT EEQL KDIF SEVG PVVS FRLV YDRE TGKP KGYG FCEY QDQE TALS AMRN LNGR EFSG RALR VDNA ASEK NKEE LKSL GTGA PVIE SPYG ETIS PEDA PESI SKAV ASLP PEQM FELM KQMK LCVQ NSPQ EARN MLLQ NPQL AYAL LQAQ VVMR
Gene ID:1478
Uniprot:P33240
Cellular Location:Nucleus
Calculated MW:59kDa/60kDa
Observed MW:61kDa
Synonyms:CSTF2, CstF-64
Background:This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.
UniProt Protein Function:CSTF2: One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm; nucleus

Molecular Function:mRNA binding; protein binding; RNA binding

Biological Process: mRNA 3'-end processing; mRNA cleavage; nuclear mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; tRNA splicing

NCBI Summary:This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]
UniProt Code:P33240
NCBI GenInfo Identifier:461847
NCBI Gene ID:1478
NCBI Accession:P33240.1
UniProt Secondary Accession:P33240,Q5H951, Q6LA74, Q8N502,
UniProt Related Accession:P33240
Molecular Weight:59,251 Da
NCBI Full Name:Cleavage stimulation factor subunit 2
NCBI Synonym Full Names:cleavage stimulation factor subunit 2
NCBI Official Symbol:CSTF2  
NCBI Official Synonym Symbols:CstF-64  
NCBI Protein Information:cleavage stimulation factor subunit 2
UniProt Protein Name:Cleavage stimulation factor subunit 2
UniProt Synonym Protein Names:CF-1 64 kDa subunit; Cleavage stimulation factor 64 kDa subunit; CSTF 64 kDa subunit; CstF-64
Protein Family:Cleavage stimulation factor
UniProt Gene Name:CSTF2  
UniProt Entry Name:CSTF2_HUMAN
Anti-CSTF2 Polyclonal Antibody (CAB8116)Western blot analysis of extracts of various cell lines, using CSTF2 antibody (CAB8116) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s.

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